Biventricular pacing in a 22-year-old with repaired congenital heart disease and dilated cardiomyopathy improved ventricular dP/dt by 14% and fractional area of change by 125% at one month.
Case Report (n=1)
Does biventricular pacing improve cardiac function and symptoms in a patient with dilated cardiomyopathy associated with repaired congenital heart disease?
Biventricular pacing may be an effective alternative therapy for improving cardiac function and symptoms in patients with dilated cardiomyopathy associated with repaired congenital heart disease.
Biventricular, alternative, and multisite pacing are currently being explored to improve cardiac function among patients with medically refractory, end-stage dilated cardiomyopathies. Although, due to inherent myocardial abnormalities, patients with repaired congenital heart defects may be at a greater risk than others to develop heart failure, often requiring cardiac transplantation. The efficacy of biventricular pacing among these patients is unknown. This report presents a patient with successfully repaired congenital heart disease in infancy who developed a symptomatic dilated cardiomyopathy at 22 years of age. Following biventricular pacing, systemic ventricular function showed a 14% improvement in ventricular dP/dt. One month later, subjective symptoms improved and cardiac ultrasound illustrated a 125% increase in fractional area of change. Exercise stress testing showed a 17% improvement in aerobic work capacity.
Rodriguez‐Cruz et al. (Thu,) conducted a case report in Dilated cardiomyopathy associated with congenital heart disease (n=1). Biventricular pacing was evaluated on Ventricular dP/dt, fractional area of change, and aerobic work capacity. Biventricular pacing in a 22-year-old with repaired congenital heart disease and dilated cardiomyopathy improved ventricular dP/dt by 14% and fractional area of change by 125% at one month.