Laparoscopic sleeve gastrectomy in adolescents with severe obesity reduced fasting insulin from 57.9 to 15.5 μIU/L at 1 year and achieved 100% remission of hypertension and type 2 diabetes.
Cohort (n=60)
No
Does laparoscopic sleeve gastrectomy improve metabolic disorders and weight in adolescents with severe obesity?
Laparoscopic sleeve gastrectomy is effective for improving metabolic disorders in adolescents with severe obesity, but requires systematic postoperative nutritional monitoring due to declining nutritional indicators.
OBJECTIVE: ). METHODS: From May 2023 to September 2024, a total of 60 adolescent patients with grade IV obesity who underwent LSG at the Department of Bariatric and Metabolic Diseases, The First Hospital of Hebei Medical University, were enrolled as the initial study cohort. Observations and statistics were collected on surgical-related complications, body weight, (Body Mass Index) BMI, glucose metabolism indicators, lipid metabolism indicators, liver function, and nutritional status to analyze the safety and efficacy of the procedure. RESULTS: ], uric acid .preoperative (491.5 ± 92.4) μmoL/L, 1-year postoperative (376.8 ± 23.6) μmoL/L, liver function, blood lipids, glycated hemoglobin, and fasting insulin .preoperative (57.9 ± 17.6) μIU/L, 1-year postoperative (15.5 ± 6.2) μIU/L Preoperatively, 12 patients had hypertension, 8 had type 2 diabetes mellitus, 4 had Polycystic Ovary Syndrome (PCOS), and 10 had Non-Alcoholic Fatty Liver Disease (NAFLD). At 1-year after surgery, all patients with hypertension and type 2 diabetes mellitus achieved remission criteria. In addition, imaging findings and liver function improved significantly in 7 of the 10 patients with fatty liver disease, and clinical manifestations improved in 3 of the 4 patients with polycystic ovary syndrome. Concurrently, a declining trend (p < 0.05) was observed postoperatively in hemoglobin, trace elements (calcium, iron), and vitamins (Vitamin D, Vitamin B12), although all values remained within the normal range. CONCLUSION: LSG is a safe and effective procedure for improving metabolic disorders in adolescent patients with grade IV obesity, with confirmed short-term efficacy. However, the widespread declining trend in postoperative nutritional indicators underscores that systematic nutritional monitoring and intervention must be a core component of postoperative management in clinical practice to achieve long-term health benefits.
Guo et al. (Thu,) conducted a cohort in Grade IV/V obesity (n=60). Laparoscopic sleeve gastrectomy vs. Preoperative baseline was evaluated on Safety and efficacy (surgical-related complications, body weight, BMI, metabolic indicators, nutritional status). Laparoscopic sleeve gastrectomy in adolescents with severe obesity reduced fasting insulin from 57.9 to 15.5 μIU/L at 1 year and achieved 100% remission of hypertension and type 2 diabetes.