Elevated urinary noradrenaline was present in approximately 25% of patients with sustained essential hypertension and was related only to the severity of blood pressure.
Observational
Does urinary noradrenaline excretion correlate with physiological and clinical characteristics in patients with essential hypertension?
Elevated urinary noradrenaline in essential hypertension is associated with the severity of blood pressure elevation rather than other physiological characteristics like plasma volume or sympathetic responsiveness.
Summary: Urinary catecholamine excretion has been measured in patients with sustained essential hypertension, borderline hypertension, secondary hypertension, and in subjects with normal blood pressure. The urinary noradrenaline level was elevated in approximately 25% of patients with sustained essential hypertension, but was normal in all patients with borderline hypertension and secondary hypertension. The relationship of elevated noradrenaline levels to certain physiological and clinical characteristics of essential hypertensives that might be related to in-creased catecholamine production has been investigated. Of the characteristics studied, plasma volume, the responsiveness of the sympathetic nervous system, renin-angiotensin status, indices of emotional stress, and “hyperkinetic circulatory state”, all proved to be unrelated to basal noradrenaline excretion. Urinary noradrenaline was related only to the level of the blood pressure, being highest in patients with more severe hypertensive disease.
Esler et al. (Sun,) conducted a observational in Hypertension. Elevated urinary noradrenaline vs. Normal urinary noradrenaline was evaluated on Relationship to physiological and clinical characteristics including blood pressure level. Elevated urinary noradrenaline was present in approximately 25% of patients with sustained essential hypertension and was related only to the severity of blood pressure.