High arterial stiffness (CAVI ≧8.1) was associated with a higher risk of incident CKD events compared to lower arterial stiffness (HR 1.3; 95% CI 1.1-1.5).
Cohort (n=24,297)
Yes
Is higher arterial stiffness (CAVI ≧8.1) associated with an increased risk of kidney dysfunction in adults without baseline CKD?
Greater arterial stiffness (CAVI ≧8.1) is associated with a significantly higher risk of developing incident chronic kidney disease events among adults with normal baseline kidney function.
Hazard Ratio: 1.3 (95% CI 1.1–1.5)
Abstract BACKGROUND Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD). METHODS We analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR) 60 ml/min/1.73 m2. We compared 2 groups of CAVI measurements—the highest quartile (≧8.1) and the combined lower 3 quartiles (8.1). We used Cox proportional hazards models to assess associations between these 2 groups and subsequent CKD events, proteinuria, eGFR 60 ml/min/1.73 m2, and rapid eGFR decline (greater than or equal to −3 ml/min/1.73 m2 per year). RESULTS The mean age of the 24,297 included participants was 46.2 years, and 60% were female. Over a mean follow-up of 3.1 years, 1,435 CKD events occurred. In a multivariable analysis, the hazard ratios with 95% confidence intervals (CIs) for the highest vs. combined lower quartiles of CAVI measurements were 1.3 (1.1, 1.5) for CKD events, 1.3 (0.96, 1.62) for proteinuria, 1.4 (1.1, 1.7) for eGFR 60 ml/min/1.73 m2, and the odds ratio with 95% CI was 1.3 (1.1, 1.4) for rapid eGFR decline. CONCLUSIONS Persons with CAVI measurements ≧8.1 had a higher risk for CKD events compared with their counterparts with CAVI measurements 8.1. Greater arterial stiffness among adults without CKD may be associated with kidney dysfunction.
Itano et al. (Wed,) conducted a cohort in Without chronic kidney disease (n=24,297). High arterial stiffness (CAVI ≧8.1) vs. Lower arterial stiffness (CAVI <8.1) was evaluated on CKD events (HR 1.3, 95% CI 1.1-1.5). High arterial stiffness (CAVI ≧8.1) was associated with a higher risk of incident CKD events compared to lower arterial stiffness (HR 1.3; 95% CI 1.1-1.5).