线粒体自噬在脓毒症相关急性肾损伤中的机制与干预研究进展

Key Points

• To explore the mechanisms and intervention strategies of mitochondrial autophagy in sepsis-associated acute kidney injury (SA-AKI).
• Review of molecular pathways related to mitochondrial autophagy in SA-AKI.
• Analysis of regulatory mechanisms and protective effects on renal tubular epithelial cells.
• Discussion on targeted intervention strategies for clinical application.
• Mitochondrial dysfunction plays a critical role in the pathogenesis of SA-AKI.
• Mitochondrial autophagy protects renal tubular cells by removing damaged mitochondria and reducing oxidative stress.
• Targeted interventions can potentially enhance mitochondrial autophagy, offering new therapeutic approaches for SA-AKI.