Lithium intoxication caused late-onset neuroleptic malignant syndrome and subsequent death in a 45-year-old man, independent of other neuroleptic agents.
Case Report (n=1)
Clinicians should be aware that acute lithium intoxication can cause fatal neuroleptic malignant syndrome independent of other neuroleptic agents.
A 45-year-old man was admitted to our hospital after taking an intentional overdose of 90 sustained-released lithium tablets (450 mg each). The patient was stabilized with three sessions of hemodialysis. On day 7 of his hospital stay, his serum lithium level was 0.5 mEq/L. On day 10, he developed high fever, tachypnea, muscle rigidity, rhabdomyolysis, acute renal insufficiency, mental confusion, and obtundation. His creatine kinase level was 698 IU/L, serum creatinine 3.5 mg/dl. Late-onset neuroleptic malignant syndrome (NMS) was diagnosed. The patient died after developing acute renal failure and acute respiratory distress syndrome. Clinicians should be aware that lithium may cause NMS independent of other neuroleptic agents.
Gill et al. (Sun,) conducted a case report in Acute Lithium Intoxication and Neuroleptic Malignant Syndrome (n=1). Lithium overdose was evaluated on Development of neuroleptic malignant syndrome and death. Lithium intoxication caused late-onset neuroleptic malignant syndrome and subsequent death in a 45-year-old man, independent of other neuroleptic agents.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: