Abstract Gastroparesis is a chronic motility disorder marked by delayed gastric emptying without mechanical obstruction, often accompanied by nausea, vomiting, early satiety, and abdominal pain. Traditional management includes dietary interventions, prokinetic and antiemetic medications, and gastric electrical stimulation for refractory cases; yet, a significant proportion of patients suffer a considerable symptom burden. Gastric peroral endoscopic myotomy (G-POEM) has developed into a minimally invasive, pylorus-targeted treatment technique with increasing national and worldwide acceptance. This narrative review consolidates the existing information regarding the efficacy, safety, durability, and therapeutic applicability of G-POEM in the treatment of gastroparesis. A literature search was performed to uncover pertinent prospective cohorts, multicentre studies, and systematic reviews assessing clinical outcomes after G-POEM. Evidence regularly shows significant improvement in symptom severity and stomach emptying for a considerable number of suitably chosen patients. Adverse effects are infrequent and typically controllable, underscoring the procedure’s positive safety profile. Long-term follow-up data suggest that symptom response may wane with time in certain individuals; yet, repeated intervention can reinstate therapeutic benefit in some. Novel instruments, including assessments of pyloric distensibility, could aid in patient selection and outcome forecasting, although additional validation is necessary. Comparative data about surgical pyloroplasty, gastric electrical stimulation, and botulinum toxin injection are scarce, necessitating high-quality randomized trials. Collectively, the evidence substantiates G-POEM as an effective therapy alternative for refractory gastroparesis. Continued study will elucidate patient selection, durability, and its role within therapy algorithms.
Hadaki et al. (Wed,) studied this question.