Key result
Altering Bmp4 expression in the mouse myocardium recapitulates the range of atrioventricular canal defects seen in patients, identifying Bmp4 as a direct mediator of atrioventricular septation.
Why the study?
Does altering Bmp4 expression in the myocardium cause atrioventricular septation defects in a mouse model?
Does altering Bmp4 expression in the myocardium cause atrioventricular septation defects in a mouse model?
This study establishes Bmp4 as an essential myocardial signal for atrioventricular septation and provides a genetic mouse model for atrioventricular canal defects.
Authors
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Provides a mouse model for AVCDs; leaves open whether Bmp4 modulation will translate to human therapies.
Jiao et al. (2003) studied Atrioventricular canal defect (AVCD). Bmp4 gene inactivation was evaluated on Atrioventricular septation. Altering Bmp4 expression in the mouse myocardium recapitulates the range of atrioventricular canal defects seen in patients, identifying Bmp4 as a direct mediator of atrioventricular septation.
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