IL-1 Receptor Antagonist Antibodies in Idiopathic Recurrent Pericarditis

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  Figure.. Anti–Interleukin 1 Receptor Antagonist (aIL-1ra) Antibodies in Idiopathic Recurrent Pericarditis, PERIPLO Study Cohort A, The PERIPLO study plasma samples were analyzed for aIL-1ra antibodies, C-reactive protein (CRP) at sampling, and maximum CRP levels. To convert CRP to milligrams per deciliter, divide by 10. B, IL-1ra plasma levels determined by commercial enzyme-linked immunosorbent assay and shown according to antibody status and anakinra treatment. Data were analyzed using Kruskal-Wallis test followed by Dunn multiple comparison test. C, Individual inflammatory markers quantified by multiplexed bead array assay and plotted according to seropositivity for aIL-1ra antibodies. Data were analyzed using Mann-Whitney U test. Boxes indicate the 25th percentile, median, and 75th percentile. Dots represent each sample. Whiskers show the minimum and maximum ranges. D, Representative plasma samples analyzed by native polyacrylamide gel electrophoresis (PAGE) or isoelectric focusing (IEF) followed by Western blot. Molecular weights are shown in kilodaltons. OD490, optical density at a wavelength of 490 nm; suPAR, soluble urokinase plasminogen activator receptor. aP < .001. bP < .05.