Catheter-based renal sympathetic denervation significantly reduced systolic blood pressure by 20 mmHg and improved anxiety, depression, quality of life, and stress tolerance at 6 months (p<0.0001).
Observational (n=119)
Does catheter-based renal sympathetic denervation improve quality of life, anxiety, depression, and stress tolerance in patients with resistant hypertension?
Renal denervation in patients with resistant hypertension is associated with significant improvements in blood pressure, quality of life, anxiety, depression, and stress tolerance at 6 months.
Mean Difference: -20
p-value: p=<0.0001
AIMS: This study analysed quality of life (QoL), anxiety and depression, headache and stress tolerance in patients with resistant hypertension before and after renal denervation (RDN). METHODS AND RESULTS: RDN was performed in 119 patients (age 62 ± 11 years, 55% male) with resistant hypertension (office blood pressure BP 165/91 ± 22/15 mmHg), treated with 5.7 ± 0.2 antihypertensive drugs. At baseline, at three and at six months after RDN, psychological status, intensity of headache and stress tolerance were documented. Stress was induced by a multitasking situation (Wiener Determination Task DT). Depression and anxiety (hospital anxiety and depression scale) and QoL (short form-12 health survey) were investigated. Intensity of headache was measured by visual analogous scale. Systolic and diastolic BP decreased by -20 ± 2.4 and -10 ± 1.4 mmHg, respectively, six months after RDN (p<0.0001). Patients showed more correct reactions (p<0.0001), fewer errors (p<0.05) and reacted faster (p<0.001) in the DT. Patients reported an improvement in QoL (p<0.05). Furthermore, anxiety (p<0.0001) and depression (p<0.0001) scores decreased. Intensity of headache decreased after RDN (p<0.01). CONCLUSIONS: RDN is associated with reduced anxiety and depression, intensity of headache and with improved QoL and stress tolerance in patients with resistant hypertension.
Lenski et al. (Tue,) conducted a observational in resistant hypertension (n=119). Catheter-based renal sympathetic denervation vs. Baseline (pre-intervention) was evaluated on Systolic blood pressure (MD -20, p=<0.0001). Catheter-based renal sympathetic denervation significantly reduced systolic blood pressure by 20 mmHg and improved anxiety, depression, quality of life, and stress tolerance at 6 months (p<0.0001).
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