Echovirus 22 does not cleave the cap-binding complex protein p220 during replication, indicating a biology more consistent with cardioviruses than enteroviruses.
Echovirus 22 exhibits biology more consistent with cardioviruses than enteroviruses by not cleaving p220 during replication.
Previously we demonstrated that echovirus 22 is an atypical enterovirus which does not shut off host cell protein synthesis. We extend these findings by showing that echovirus 22 does not cleave p220, part of the cellular cap-binding complex necessary for cap-dependent translation, suggesting a biology more consistent with cardioviruses than enteroviruses.
Coller et al. (1991) studied this question. Echovirus 22 does not cleave the cap-binding complex protein p220 during replication, indicating a biology more consistent with cardioviruses than enteroviruses.