Physiologic and Biochemical Aspects of the Disordered Coronary Circulation

Article1 October 1959PHYSIOLOGIC AND BIOCHEMICAL ASPECTS OF THE DISORDERED CORONARY CIRCULATIONRICHARD GORLIN, M.D., NORMAN BRACHFELD, M.D., JOSEPH V. MESSER, M.D., JOHN D. TURNER, M.D.RICHARD GORLIN, M.D., NORMAN BRACHFELD, M.D., JOSEPH V. MESSER, M.D., JOHN D. TURNER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-698 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite extensive anatomicopathologic studies, the characteristics of the coronary circulation responsible for ischemic heart disease have not been quantitatively defined. Recent advances in the measurement of coronary blood flow, combined with the technic of coronary sinus catheterization,1a, b, c have resulted in a physiologic approach to the dynamics of coronary flow in man. It is the purpose of this report to present the hemodynamic and biochemical characteristics of the coronary circulation in patients with angina pectoris. Our findings are based on a correlative clinical, electrocardiographic and cardiac catheterization study of 50 patients.Coronary sinus catheterization was performed with measurement of...Bibliography1. EckenhoffHafkenschielHarmelGoodaleLubinBingKety JEJHMHWTMRJSS(a) : Measurement of coronary blood flow by the nitrous oxide method, Am. J. Physiol. 152: 356, 1948. (b) Goodale, W. T., and Hackel, D.: Measurement of coronary blood flow in dogs and man from rate of myocardial nitrous oxide desaturation, Circul. Res. 1: 502, 1953. (c) Bing, R. J., Hammond, M. M., Handelsman, J. C., Powers, S. R., Spencer, F. C., Eckenhoff, J. E., Goodale, W. T., Hafkenschiel, J. H., and Kety, S. S.: The measurement of coronary blood flow, oxygen consumption and efficiency of the left ventricle in man, Am. Heart J. 38: 1, 1949. 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EldridgeHultgrenStewartProctor FLHNPD: The effect of nitroglycerin upon the cardiovascular system, Stanford M. Bull. 13: 273, 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 20, 1959.From the Medical Clinics, Peter Bent Brigham Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts.†Investigator, Howard Hughes Medical Institute. This work was supported by grants from the U. S. Public Health Service (N.I.H. H-2637), Kriendler Memorial Foundation, Wyeth Laboratories, Massachusetts Heart Association and Warner-Chilcott Laboratories.Requests for reprints should be addressed to Richard Gorlin, M.D., Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston 15, Massachusetts. 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