Chronic electrical stimulation of rabbit motor nerves induced asynchronous replacement of fast by slow myosin isoforms without recapitulating the developmental sequence.
Does chronic electrical stimulation of the motor nerve induce sequential replacement of myosin subunit isoforms in fast skeletal muscles of the rabbit?
Chronic electrical stimulation of rabbit fast skeletal muscle induces asynchronous replacement of fast by slow myosin isoforms without recapitulating the developmental sequence.
Fiber type transformation was induced in fast skeletal muscles of the rabbit by chronic electrical stimulation of the motor nerve. The accompanying changes in myosin subunit composition were examined in order to establish the precise sequence of events during this transition. Replacement of the fast by the slow isoforms of the individual light and heavy chains of the native myosin did not occur synchronously. The resultant changes in the stoichiometry of the different classes of light chains are described in relation to possible mechanisms regulating the expression of the corresponding genes. The neonatal form of myosin could not be detected at any stage of transformation, suggesting that the changes in myosin synthesis do not recapitulate the developmental sequence.
Brown et al. (Thu,) conducted a other in Muscle type transformation. Chronic electrical stimulation of the motor nerve was evaluated on Changes in myosin subunit composition. Chronic electrical stimulation of rabbit motor nerves induced asynchronous replacement of fast by slow myosin isoforms without recapitulating the developmental sequence.