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Abstract Normal human sera, including autologous sera, contain complement-dependent lymphocytotoxic antibodies to Vibrio cholera neuraminidase-treated human peripheral blood lymphocytes and human lymphoid cells maintained in long-term tissue culture, but not to untreated cells. Carbohydrate hapten inhibition studies showed that these antibodies were inhibited by oligosaccharides containing β-d-galactosyl nonreducing end residues, indicating that the antigenic determinant is at least in part carbohydrate. There is evidence for both antigen and antibody heterogeneity.
Rogentine et al. (Sun,) studied this question.