Clinical Studies With the AId of Radio-Phosphorus. Iv. The Retention in Blood, the Excretion and the Therapeutic Effect of Radio-Phosphorus on Patients With Leukemia

Article1 September 1941CLINICAL STUDIES WITH THE AID OF RADIO-PHOSPHORUS. IV. THE RETENTION IN BLOOD, THE EXCRETION AND THE THERAPEUTIC EFFECT OF RADIO-PHOSPHORUS ON PATIENTS WITH LEUKEMIAL. A. ERF, M.D., L. W. TUTTLE, J. H. LAWRENCE, M.D.L. A. ERF, M.D.Search for more papers by this author, L. W. TUTTLESearch for more papers by this author, J. H. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-3-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies19, 20, 21, 22, 34, 35have shown that radiophosphorus (15P32) (which owes its radioactivity to the spontaneous emission of beta rays) when administered in the form of sodium phosphate, at first concentrates in the bone marrow and those tissues infiltrated with leukemic cells and later concentrates in the osseous tissues. Radio-phosphorus has been used as a therapeutic agent during the past three years in all types of leukemia, with encouraging results. The principal advantages offered by radio-phosphorus appear to lie in its ease of administration (it may be given orally, intravenously, etc.), in its therapeutic effectiveness and in...References1. BLUMCOMBS LS: Chronic lymphatic leukemia complicated by Type III pneumococcus pneumonia. Recovery from pneumonia with sulfapyridine and serum, Jr. Indiana State Med. Assoc., 1940, 424. Google Scholar2. BRUES DT: Food, drink and evolution, Science, 1939, xc, 145. CrossrefGoogle Scholar3. CASTLEMEYERCHEW WBOOWB: Negative results of treatment of chronic myelogenous leukemia as a deficiency disease, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 660. CrossrefGoogle Scholar4. CRAVERMACCOMB LFWS: Irradiation of entire body; Heublein method, N. Y. State Jr. Med., 1934, xxxiv, 249. Google Scholar5. ERF LA: Clinical studies with the aid of radio-phosphorus. II. The retention of radio-phosphorus by tissues of patients dead of leukemia (to be published in Am. Jr. Med. Sci.). Google Scholar6. ERF LA: The disappearance of intravenously injected lymphocytes in the absence of the gastrointestinal tract, Am. Jr. Med. Sci., 1940, cc, 1. CrossrefGoogle Scholar7. ERFFINE LAA: Serial blood and bone marrow findings of an eighth-month premature and its roentgen-ray treated chronic myeloid leukemic mother, Am. Jr. Med. Sci., 1938, cxcv, 8. CrossrefGoogle Scholar8. ERFTUTTLESCOTT LALWKG: The retention of orally administered radio-phosphorus by mice, Proc. Soc. Exper. Biol. and Med., 1940, xlv, 652. CrossrefGoogle Scholar9. ERFRHOADS LACP: The hematological effects of benzene (benzol) poisoning, Jr. Ind. Hyg. and Tox., 1939, xxi, 421. Google Scholar10. FORKNER CE: Leukemia and allied disorders, 1938, Macmillan Co., New York. CrossrefGoogle Scholar11. HESS W: Respiration and fermentation of tissue in leukemia produced by benzene, Frankfurt. Ztschr. f. Path., 1935, xlvii, 522. Google Scholar12. IWATSURANANJO RK: Phosphatase activity of blood serum and urine in chronic myeloid leukemia, Biochem. Ztschr., 1939, ccc, 422. Google Scholar13. JAFFE RH: Tuberculosis and leukemia, Am. Rev. Tuberc., 1933, xxvii, 32. Google Scholar14. JONES EI: Intestinal ulceration in myelogenous leukemia, Lancet, 1940, i, 174. CrossrefGoogle Scholar15. KEMPNER W: The nature of leukemic blood cells as determined by their metabolism, Jr. Clin. Invest., 1939, xviii, 291. CrossrefGoogle Scholar16. KENSLERSUGIURAYOUNGHALTERRHOADS CJKNFCRCP: Partial protection of rats by riboflavin with casein against liver cancer caused by dimethylaminoazobenzene (butter yellow), Science, 1941, xciii, 308. CrossrefGoogle Scholar17. LAVIKBAUMANN PSCA: Dietary fat and tumor formation, Cancer Research, 1941, i, 181. Google Scholar18. LAWRENCECOOKSEY EOD: On the apparatus for the multiple acceleration of light ions to high speeds, Phys. Rev., 1936, l, 1131. CrossrefGoogle Scholar19. LAWRENCESCOTT JHKG: Comparative metabolism of phosphorus in normal and lymphomatous animals, Proc. Soc. Exper. Biol. and Med., 1939, xl, 694. CrossrefGoogle Scholar20. LAWRENCESCOTTTUTTLE JHKGLW: Studies on leukemia with the aid of radioactive phosphorus, Internat. Clin., 1939, iii, 33. Google Scholar21. LAWRENCETUTTLESCOTTCONNOR JHLWKGCL: Studies on neoplasms with the aid of radioactive phosphorus. I. The total phosphorus metabolism of normal and leukemic mice, Jr. Clin. Invest., 1940, xix, 267. CrossrefGoogle Scholar22. LAWRENCE JH: Nuclear physics and therapy; preliminary report on a new method for the treatment of leukemia and polycythemia, Radiology, 1940, xxxv, 51. CrossrefGoogle Scholar23. LEWISOHNLEUCHTENBERGERLEUCHTENBERGERLASZLO RCRD: Effect of intravenous injections of yeast extract on spontaneous breast adenocarcinomas in mice, Proc. Soc. Exper. Biol. and Med., 1940, xliii, 558. CrossrefGoogle Scholar24. LEWSEN SC: Leukemia following trauma, Lancet, 1930, i, 288. CrossrefGoogle Scholar25. LIVINGSTONMOORE KERD: Reaction of leukemic patients to sulfapyridine administration, New Eng. Jr. Med., 1940, ccxxiii, 975. CrossrefGoogle Scholar26. MARSHAK A: Uptake of radioactive phosphorus by nuclei of liver and tumors, Science, 1940, xcii, 460. CrossrefGoogle Scholar27. MEYERMIDDLETONTHEWLIS OOWSEW: Therapeutic failure with certain organic substances in leukemia, Folia Haemat., 1935, liii, 166. Google Scholar28. MURPHY WP: Conservative x-ray treatment in chronic leukemia, Jr. Am. Med. Assoc., 1940, cxv, 1156. CrossrefGoogle Scholar29. OTT A: Involvement of the gastrointestinal tract in leukemic and similar diseases of the hematopoietic system, Virchow's Arch. f. path. Anat., 1936, ccxcvii, 548. CrossrefGoogle Scholar30. RHOADSBARKERMILLER CPWHDK: Increased susceptibility to hemolysis by indol in dogs fed deficient diets, Jr. Exper. Med., 1938, lxvii, 299. CrossrefGoogle Scholar31. SABINDUFFY ABCE: Nutrition as a factor in the development of constitutional barriers to involvement of the nervous system by certain viruses, Science, 1940, xci, 552. CrossrefGoogle Scholar32. STÖGER R: Clinical aspects and therapy of lymphatic leukemia, München. med. Wchnschr., 1940, 1047. Google Scholar33. SUGIURARHOADS KCP: Experimental liver cancer in rats and its inhibition by rice-bran extract, yeast and yeast extract, Cancer Research, 1941, i, 3. Google Scholar34. TUTTLEERFLAWRENCE LWLAJH: Studies on neoplasms with the aid of radioactive phosphorus. II. The phosphorus metabolism of the nucleoprotein, phospholipid and acid soluble fractions of normal and leukemic mice, Jr. Clin. Invest., 1941, xx, 57. CrossrefGoogle Scholar35. TUTTLESCOTTLAWRENCE LWKGJH: Phosphorus metabolism in leukemic blood, Proc. Soc. Exper. Biol. and Med., 1939, xli, 20. CrossrefGoogle Scholar36. USSING H: Use of amino acids containing deuterium to follow protein production in the organism, Nature, 1938, cxlii, 399. CrossrefGoogle Scholar37. VERZAR F: Absorption from the intestines, 1936, Longmans, Green & Co. Google Scholar38. WEBSTER LT: Heredity in infectious diseases, Jr. Heredity, 1939, xxx, 365. CrossrefGoogle Scholar39. YAGUDAROSENTHAL AN: Relation of trauma to leukemia, Am. Jr. Clin. Path., 1939, ix, 311. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Berkeley, California*Received for publication May 7, 1941.Aided by a grant from the Blanche and Frank Wolf Fund of the University of California.†Wm. R. Kenan, Jr., Fellow. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProposed biokinetic model for phosphorusAppendixesBIBLIOGRAPHYAppendixesDer Einfluß der Phosphor-Aufnahme auf die Ausscheidung und Retention von parenteral verabreichtem 32P nach Untersuchungen an ausgewachsenen SchweinenHistorische Übersicht der Anwendung von IsotopindicatorenBlutkrankheitenAn evaluation of the effect of pregnancy on chronic granulocytic leukemiaÜber die Resorption von anorganischen Stoffen durch die menschliche HautDer Mineralstoffwechsel der ZelleUPTAKE OF RADIOPHOSPHATE IN THYROID AND LYMPHATIC TISSUE OF YOUNG GUINEA PIGS AFTER SUBTOTAL THYMECTOMYBlutkrankheitenPhosphorusTierversuche über Aufnahme und Verteilung von radioaktivem PhosphatRadioactive phosphorus. II. In the treatment of myeloid leukemiaBibliographyMULTIPLE MYELOMA: A STUDY OF 24 PATIENTS TREATED WITH RADIOACTIVE ISOTOPES (P32 AND SR88)*JOHN H. LAWRENCE, M.D., LOUIS R. WASSERMAN, M.D., F.A.C.P.The effect of temperature upon the uptake of radioactive phosphate by human erythrocytes in vitroThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.III. Erythrocytes—with deviations of observations from predicted valuesThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.IV. Leukocytes—radioactive phosphorus content and the relation to plasma-P32 levelsThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.I. Whole blood—with deviations of observations from predicted values and an estimate of total-phosphorus turnover rateAnwendungen der stabilen und radioaktiven Isotope in der BiochemieRadiophosphorus in the Treatment of Blood DyscrasiasRadioactive Phosphorus (P32) and Alkylamines (Nitrogen Mustards) in the Treatment of Neoplastic and Allied Diseases of the Hemofoietic SystemLeucemia and Pregnancy 1 September 1941Volume 15, Issue 3Page: 487-543KeywordsAIDSBloodBone marrowCellsChildrenExcretionPhosphatesRadiation therapyResearch laboratoriesSodium ePublished: 1 December 2008 Issue Published: 1 September 1941 PDF downloadLoading ...