Digitalis Intoxication: A Clinical Report of 148 Cases

Article1 April 1959DIGITALIS INTOXICATION: A CLINICAL REPORT OF 148 CASESDIETEGEN VON CAPELLER, M.D., G. DANIEL COPELAND, M.D., THOMAS N. STERN, M.D.DIETEGEN VON CAPELLER, M.D.Search for more papers by this author, G. DANIEL COPELAND, M.D.Search for more papers by this author, THOMAS N. STERN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-4-869 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEver since 1785, when William Withering first described the clinical use ofDigitalis purpureain the treatment of congestive heart failure, cases of intoxication with this drug have been reported. Withering also gave us the first accurate account of digitalis intoxication. In his monograph he states: "Foxglove, when given in very large and repeated doses, occasions sickness, vomiting, purging, giddiness, confused vision, objects appearing green or yellow, increased secretion of urine, with frequent motions to part with it, and sometimes inability to retain it; slow pulse, even as slow as 35 in a minute, cold sweats, convulsions, syncope, death."1...Bibliography1. Withering W: An account of the foxglove and some of its medical uses with practical remarks on dropsy and other diseases, 1785, Robinson, Birmingham. Google Scholar2. Katz LN: Electrocardiography: including an atlas of electrocardiograms, 1946, Lea and Febiger, Philadelphia. Google Scholar3. Goldberger E: Unipolar lead electrocardiography and vectorcardiography, 1953, Lea and Febiger, Philadelphia. Google Scholar4. CrouchHerrmannHejtmancik RBGRMR: Digitalis intoxication, Texas State J. Med. 52: 714-719, 1956. MedlineGoogle Scholar5. HerrmannDecherdMcKinley GRGMWF: Digitalis poisoning, J. A. M. 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LinkGoogle Scholar13. Kyser FA: The role of digitalis intoxication in refractory heart failure, Quart. Bull., Northwestern Univ. M. School 29: 158-161, 1955. Google Scholar14. LownLevine BSA: Current concepts in digitalis therapy, 1954, Little, Brown and Company, Boston. Google Scholar15. Heyl AF: Auricular paroxysmal tachycardia caused by digitalis: report of case, Ann. Int. Med. 5: 858-872, 1932. LinkGoogle Scholar16. Levine SA: Clinical heart disease, 1951, W. B. Saunders Company, Philadelphia. CrossrefGoogle Scholar17. ZimdahlTownsend WTCE: Bidirectional ventricular tachycardia due to digitalis poisoning: response to potassium therapy and evaluation of arrhythmia mechanism, Am. Heart J. 47: 304-312, 1954. CrossrefMedlineGoogle Scholar18. WilsonHall OGRE: Paroxysmal tachycardia with alternating direction of ventricular complexes due to digitalis intoxication: case report, Ohio State M. J. 51: 1199, 1955. MedlineGoogle Scholar19. 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Author, Article, and Disclosure InformationAffiliations: Memphis, Tennessee*Received for publication November 22, 1957.From the Department of Medicine, University of Tennessee, and the City of Memphis Hospitals, Memphis, Tennessee.†Currently, Member, Department of Medicine, The Jackson Clinic, Jackson, Tennessee.Requests for reprints should be addressed to Thomas N. Stern, M.D., Division of Medicine, The University of Tennessee, 858 Madison Avenue, Memphis 3, Tennessee. 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BURCHELL, M.D., PH.D.CARDIOVASCULAR TOXICITY*Problems in the use of digitalis in the management of congestive heart failureThe possible role of sex in digitalis toleranceAccidental digitalis intoxication in childrenEffect of digitalis on conduction of the heartThe effects of digitalis bodies on patients with heart block and congestive heart failureEstrogen effect in exfoliated vaginal cells following treatment with digitalisDeliberate Digitalis Intoxication A Comparison of the Toxic Effects of Four Glycoside PreparationsG. CHURCH, M.B., F.R.F.P.S., L. SCHAMROTH, M.B., M.R.C.P., NEIL L. SCHWARTZ, M.B., M.R.C.P., HENRY J. L. MARRIOTT, M.A., B.M.Digitalis intoxication — management and preventionProgressive electrocardiographic changes associated with digitalis in the presence of complete A-V heart block: an experimental studyKinetocardiographic findings in patients with congestive heart failure and changes after therapeutic digitalizationSome aspects of the clinical pharmacology of digitalisThe treatment of digitalis toxicityThe toxicology of digitalis∗Arrhythmias and conduction disturbances due to digitalisTherapie der HerzinsuffizienzDigitalis intoxication 1 April 1959Volume 50, Issue 4Page: 869-878KeywordsArrhythmiaElectrocardiographyIntoxicationNauseaSweatSyncopeTachycardiaUrineVisionVomiting ePublished: 1 December 2008 Issue Published: 1 April 1959 PDF downloadLoading ...