Identification of Urate Crystals in Gouty Synovial Fluid

Article1 March 1961IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUIDDANIEL J. MCCARTY, M.D., JOSEPH L. HOLLANDER, M.D., F.A.C.P.DANIEL J. MCCARTY, M.D., JOSEPH L. HOLLANDER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-3-452 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUrate crystals have been noted in synovial fluid from gouty patients in the past, but this finding was believed to be infrequent and of little assistance to the clinician in his attempt to establish a diagnosis.1Recently one of us2reported that eight of 17 fluids from the affected joints of patients with clinical gout contained crystals seen by ordinary light microscopy, and in several of these cases the diagnosis of gout was first established on the basis of this finding.2It was noted that urate crystals in joint fluid were often short and rod-shaped, with rounded ends and parallel...Bibliography1. BauerCalkins WE, in Diseases of metabolism, edited by G. G. Duncan, p. 659. W. B. Saunders Co., Philadelphia, Pa., 1959. Google Scholar2. Hollander JL: Arthritis and allied conditions, 6th Ed., p. 77. Lea partial inhibition by golchicine and indomethacinPolymorphonuclear leukocyte motility in vitro. III. Possible release of a chemotactic substance after phagocytosis of urate crystals by polymorphonuclear leukocytesSome Relationships among Hemostasis, Fibrinolytic Phenomena, Immunity, and the Inflammatory ResponseTHE DIAGNOSTIC IMPORTANCE OF SYNOVIAL FLUID ANALYSISLaboratory Studies in the Diagnosis of Rheumatoid ArthritisSuppression of urate crystal-induced canine joint inflammation by heterologous anti-polymorphonuclear leukocyte SerumMEDIATORS OF PAINChondrocalcinosis and chondrocalsynovitis (pseudogout syndrome)The Varying Picture in GoutAcute arthritisArthritis—An Example of Inflammation Based on ParticlesThe Clinical Significance of Deoxyribonucleic Acid Particles in Synovial FluidTHOMAS J. PEKIN JR., M.D., THEODORE M.D., J. of Synovial Fluid as a in model of acute inflammation in in the Treatment of M.D., F.A.C.P., N. M.D., H. and acid: A of on human in Gicht in clinical of gouty arthritis clinical of the in the elimination of uric of acute of gouty in Study of Uric Acid and into the of gouty on the Pathogenesis of Rheumatoid Joint Inflammation The and a Working HOLLANDER, M.D., F.A.C.P., J. MCCARTY JR., M.D., F.A.C.P., M.D., of Gout in the Fluid Evaluation in Joint in the Diagnosis of and Arthritis of American and of Rheumatism J. M.D., F.A.C.P., L. M.D., M.D., L. M.D., M.D., F.A.C.P., JOSEPH HOLLANDER, M.D., F.A.C.P., M.D., F.A.C.P., M.D., F.A.C.P., M.D., F.A.C.P., A. M.D., L. M.D., F.A.C.P., J. WEINBERGER, M.D., of in gout: crystals to hyperuricemia and acute arthritis in failure treated with Crystals in Synovial M.D., M.D., JR., M.D., W. and Hyperuricemia after for of Uric Acid and Its to of Gouty old and new of acute gouty joints, an ARTHRITIS IN AND OF URATE Significance of Calcium Crystals in the Synovial Fluid of The Clinical J. MCCARTY JR., M.D., N. M.D., Significance of Calcium Crystals in the Synovial Fluid of The II. Identification of N. M.D., J. MCCARTY JR., M.D., Treatment of Gout March acid March PDF