Obesity (OR 1.60; 95% CI 1.06-2.41) and overweight (OR 1.52; 95% CI 1.04-2.22) were associated with a significantly higher risk of left ventricular diastolic dysfunction than normal weight.
Observational (n=950)
Does increased BMI (overweight and obesity) worsen left ventricular diastolic function compared to normal weight?
Increased BMI is independently associated with worse LV diastolic function, which may partially explain the increased risk of heart failure in overweight and obese individuals.
Odds Ratio: 1.6 (95% CI 1.06–2.41)
Objectives To assess the independent effect of increased body size on left ventricular (LV) diastolic function. Background Obese and overweight individuals are at increased risk of heart failure. LV diastolic dysfunction is an asymptomatic condition associated with future heart failure. It is unclear whether obesity and overweight are independently associated with LV diastolic dysfunction. Methods LV diastolic function was evaluated in 950 participants from the Cardiovascular Abnormalities and Brain Lesions (CABL) study by traditional and tissue-Doppler imaging. Peak early and late trans-mitral diastolic flow velocities (E, A) and early diastolic mitral annulus velocity (E′) were measured, and E/A and E/E′ were calculated. The study sample was divided into three groups: normal weight body mass index (BMI)<25.0, overweight (BMI 25.0–29.9) and obese (BMI≥30). Results In multivariate analyses, BMI was independently associated with higher E, A, and E/E′, an indicator of LV filling pressure (all p≤0.01). Overweight and obese had lower E′ (both p<0.01) and higher E/E′ (both p<0.01) than normal weight participants. E/A was lower in obese than normal weight subjects (p<0.01). The risk of diastolic dysfunction was significantly higher in overweight (adjusted odds ratio: 1.52, 95% confidence intervals 1.04–2.22) and obese (adjusted odds ratio: 1.60, 95% confidence intervals 1.06–2.41) compared to normal weight individuals. Conclusions Increased BMI was associated with worse LV diastolic function independent of LV mass and associated risk factors. The increased risk of LV diastolic dysfunction in both overweight and obese individuals may partially account for the increased risk of heart failure associated with both conditions.
Russo et al. (Tue,) conducted a observational in Left ventricular diastolic dysfunction (n=950). Obesity (BMI ≥30) and overweight (BMI 25.0-29.9) vs. Normal weight (BMI <25.0) was evaluated on Diastolic dysfunction (OR 1.60, 95% CI 1.06-2.41). Obesity (OR 1.60; 95% CI 1.06-2.41) and overweight (OR 1.52; 95% CI 1.04-2.22) were associated with a significantly higher risk of left ventricular diastolic dysfunction than normal weight.