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Summary A dentist developed acute, icteric HBsAg-positive hepatitis despite the prior existence of anti-HBs. Evaluation of this antibody showed it to have a restricted specificity reacting with only one subdeterminant (α1) of the hepatitis B surface antigen. The anti-HBs/α1 coexisted with HBsAg of subtype ayw in the acute phase hepatitis serum.
Koziol et al. (1976) studied this question.