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Most trial-level validation studies of surrogate end points in oncology find low correlations with survival. All validation studies use only a subset of available trials. The evidence supporting the use of surrogate end points in oncology is limited.
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Vinay Prasad
Nationwide Children's Hospital
Chul Kim
Inje University
Mauricio Burotto
Universidad de Los Andes, Chile
JAMA Internal Medicine
National Institutes of Health
University of California, Los Angeles
National Cancer Institute
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Prasad et al. (Mon,) studied this question.
synapsesocial.com/papers/69d98abf8988aeabbe685a59 — DOI: https://doi.org/10.1001/jamainternmed.2015.2829