Elevated brachial-ankle pulse wave velocity was significantly associated with an increased prevalence of coronary artery calcification in Japanese men, with a multivariable-adjusted OR of 2.20.
Cross-Sectional (n=986)
Is elevated brachial-ankle pulse wave velocity associated with an increased prevalence of coronary artery calcification in CVD-free Japanese men?
Elevated brachial-ankle pulse wave velocity is independently associated with an increased prevalence of coronary artery calcification in Japanese men, supporting its utility as a marker for subclinical atherosclerosis.
Effect estimate: OR 2.20 (95% CI 1.22-3.96)
Absolute Event Rate: 66.7% vs 20.6%
p-value: p=0.042
AIM: Pulse wave velocity (PWV) is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC) is an intermediate stage in the process leading to overt cardiovascular disease (CVD) and an established determinant of coronary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men. METHODS: This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV) was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores ≥ 10 were defined as the presence of CAC. RESULTS: Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles ＜ 1378, 1378-1563, 1564-1849, and ＞ 1849 cm/s (P ＜ 0.001 for trend). Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P=0.042 for trend). The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis. CONCLUSIONS: Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men.
Torii et al. (Thu,) conducted a cross-sectional in Coronary Artery Calcification (n=986). Elevated brachial-ankle pulse wave velocity (baPWV) vs. Lowest quartile of baPWV (<1378 cm/s) was evaluated on Presence of Coronary Artery Calcification (Agatston score ≥ 10) (OR 2.20, 95% CI 1.22-3.96, p=0.042). Elevated brachial-ankle pulse wave velocity was significantly associated with an increased prevalence of coronary artery calcification in Japanese men, with a multivariable-adjusted OR of 2.20.