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The interaction of insulin with its receptor was studied in purified liver plasma membranes and isolated hepatocytes of the obese hyperglycemic mouse (ob/ob) and its thin litter mate.The ob/ob mouse is a genetic mutant characterized by marked obesity, hyperinsulinism, and resistance to both endogenous and exogenous insulin.Under identical condi-
Kahn et al. (Mon,) studied this question.
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