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We have investigated the macrophage-binding properties of normal murine B cells and found that only a defined subpopulation of B cells can bind to macrophages. This subpopulation corresponds to the Lyb3--positive subpopulation. A population of T cells exists that disrupts this macrophage-B cell interaction. These findings are discussed in light of the demonstrated dependence on macrophages of several Lyb3+ cell functions.
O’Toole et al. (Tue,) studied this question.