Circulating IL-10 levels were significantly higher in patients with congestive heart failure compared to normal subjects (p<0.05), suggesting activation of the IL-10 system to downregulate TNFalpha.
Observational (n=99)
Are circulating levels of the anti-inflammatory cytokine IL-10 and its receptor upregulated in patients with congestive heart failure compared to healthy controls?
The IL-10 and IL-10 receptor system is activated in patients with advanced heart failure, likely as a compensatory mechanism to downregulate excess proinflammatory TNF-alpha.
p-value: p=<0.05
Proinflammatory cytokines, i.e., tumor necrosis factor-alpha (TNFalpha), participate in the development and the progression of congestive heart failure (CHF). On the other hand, an anti-inflammatory cytokine may neutralize the proinflammatory cytokines of CHF. Interleukin-10 (IL-10) is known to suppress the synthesis of proinflammatory cytokines. IL-10 and the IL-10 receptor system was investigated in comparison with the behavior of TNFalpha in 68 patients with various causes of CHF (mean age: 61 years) and in 31 normal subjects (61 years). The circulating IL-10 level was higher in CHF patients than in normal subjects (p<0.05). The TNFalpha level was higher in CHF patients than in control subjects (p<0.005). The ratio of IL-10 to TNFalpha tended to be higher in control subjects than in patients with CHF (p = 0.09). With lipopolysaccharide treatment, the release of IL-10 was more enhanced from mononuclear leukocyte of patients with CHF than from control subjects (p<0.05). The expression of the IL-10 receptor estimated by flow cytometry of mononuclear leukocytes was higher in the CHF patients than in the normal subjects. The IL-10/IL-10 receptor system was activated, at least partly, to downregulate an excess of TNFalpha in patients with advanced CHF. IL-10 may be an important inherent component of the cytokine network of CHF.
Yamaoka‐Tojo et al. (Fri,) conducted a observational in Congestive heart failure (n=99). Congestive heart failure vs. Normal subjects was evaluated on Circulating IL-10 level (p=<0.05). Circulating IL-10 levels were significantly higher in patients with congestive heart failure compared to normal subjects (p<0.05), suggesting activation of the IL-10 system to downregulate TNFalpha.