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In patients with early-stage breast cancer, irradiation of the regional nodes had a marginal effect on overall survival. Disease-free survival and distant disease-free survival were improved, and breast-cancer mortality was reduced. (Funded by Fonds Cancer; ClinicalTrials.gov number, NCT00002851.).
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New England Journal of Medicine
Radboud University Nijmegen
Charité - Universitätsmedizin Berlin
University Medical Center Utrecht
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Poortmans et al. (Wed,) studied this question.