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A simple method for synthesizing esters of labeled cholesterol of high specific activity is described. The formation of acyl chlorides takes 10 min and they are reacted with labeled cholesterol to form the cholesterol esters in another 5 min. Yields were 30–70% and radiopurities of 90–99.5% were achieved.
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Journal of Lipid Research
Tulane University
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Pinter et al. (Wed,) studied this question.