Initial aortic valve replacement in asymptomatic severe aortic stenosis was associated with lower 5-year incidence of all-cause death compared to a conservative strategy (15.4% vs 26.4%, p=0.009).
Cohort (n=582)
Yes
Does an initial AVR strategy reduce all-cause death and heart failure hospitalization compared to a conservative strategy in patients with asymptomatic severe aortic stenosis?
An initial surgical AVR strategy in asymptomatic severe aortic stenosis is associated with significantly lower long-term mortality and heart failure hospitalization compared to a conservative watchful waiting approach.
Absolute Event Rate: 15.4% vs 26.4%
p-value: p=0.009
BACKGROUND Current guidelines generally recommend watchful waiting until symptoms emerge for aortic valve replacement (AVR) in asymptomatic patients with severe aortic stenosis (AS). OBJECTIVES The study sought to compare the long-term outcomes of initial AVR versus conservative strategies following the diagnosis of asymptomatic severe AS. METHODS We used data from a large multicenter registry enrolling 3,815 consecutive patients with severe AS (peak aortic jet velocity >4.0 m/s, or mean aortic pressure gradient >40 mm Hg, or aortic valve area <1.0 cm(2)) between January 2003 and December 2011. Among 1,808 asymptomatic patients, the initial AVR and conservative strategies were chosen in 291 patients, and 1,517 patients, respectively. Median follow-up was 1,361 days with 90% follow-up rate at 2 years. The propensity score-matched cohort of 582 patients (n = 291 in each group) was developed as the main analysis set for the current report. RESULTS Baseline characteristics of the propensity score-matched cohort were largely comparable, except for the slightly younger age and the greater AS severity in the initial AVR group. In the conservative group, AVR was performed in 41% of patients during follow-up. The cumulative 5-year incidences of all-cause death and heart failure hospitalization were significantly lower in the initial AVR group than in the conservative group (15.4% vs. 26.4%, p = 0.009; 3.8% vs. 19.9%, p < 0.001, respectively). CONCLUSIONS The long-term outcome of asymptomatic patients with severe AS was dismal when managed conservatively in this real-world analysis and might be substantially improved by an initial AVR strategy. (Contemporary Outcomes After Surgery and Medical Treatment in Patients With Severe Aortic Stenosis Registry; UMIN000012140).
Taniguchi et al. (Thu,) conducted a cohort in Asymptomatic severe aortic stenosis (n=582). Initial aortic valve replacement vs. Conservative strategy was evaluated on All-cause death at 5 years (p=0.009). Initial aortic valve replacement in asymptomatic severe aortic stenosis was associated with lower 5-year incidence of all-cause death compared to a conservative strategy (15.4% vs 26.4%, p=0.009).
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