A higher neutrophil to lymphocyte ratio (≥3.5) independently predicted increased long-term all-cause mortality in African Americans undergoing PCI (HR 2.1; 95% CI 1.1-4; p=0.02).
Cohort (n=372)
Does a higher Neutrophil to Lymphocyte ratio predict long-term mortality in African American patients undergoing percutaneous coronary intervention?
An elevated Neutrophil to Lymphocyte ratio is a strong, independent predictor of long-term all-cause mortality in African American patients undergoing PCI, despite this population having lower baseline neutrophil counts.
Effect estimate: HR 2.1 (95% CI 1.1-4)
Absolute Event Rate: 31.1% vs 10.4%
p-value: p=0.02
BACKGROUND: Neutrophil to lymphocyte ratio (N/L ratio) has been shown to predict long-term mortality in patients undergoing percutaneous coronary intervention (PCI). African Americans have been shown to have lower mean neutrophil counts compared to whites. The usefulness of the N/L ratio in predicting long-term mortality in African Americans undergoing PCI is unknown. METHODS: We evaluated a total of 372 African American patients (327 patients with lower N/L ratio or =3.5) who underwent PCI during January 2003 to August 2005. The primary endpoint was all-cause mortality at a median follow-up to 3.6 years. RESULTS: During the median ( +/- SD) follow-up period of 3.6 +/- 1 years, there were a total of 48 deaths. The mortality rate was 10.4% in the group with a lower N/L ratio and 31.1% in the group with a higher N/L ratio (unadjusted p < 0.001). After adjustment for covariates with significant impact on mortality, N/L ratio was still a strong and independent predictor of long-term mortality with a hazard ratio (HR) of 2.1 (95% confidence interval CI: 1.1-4; p = 0.02). N/L ratio was also found to be a strong and independent predictor of long-term mortality even when analyzed as a categorical variable with 3 groups (HR of 0.39 for lower tertile compared to the upper tertile, 95% CI: 0.19-0.81; p = 0.012) and as a continuous variable (p = 0.002). CONCLUSION: N/L ratio is a powerful independent predictor of long-term mortality in African Americans undergoing PCI.
Poludasu et al. (Tue,) conducted a cohort in African Americans undergoing percutaneous coronary intervention (PCI) (n=372). Higher Neutrophil to Lymphocyte (N/L) ratio (≥3.5) vs. Lower N/L ratio (<3.5) was evaluated on All-cause mortality (HR 2.1, 95% CI 1.1-4, p=0.02). A higher neutrophil to lymphocyte ratio (≥3.5) independently predicted increased long-term all-cause mortality in African Americans undergoing PCI (HR 2.1; 95% CI 1.1-4; p=0.02).