What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy (n=542). Intervention: Cigarette smoking vs. Non-smokers. Primary outcome: Mean platelet count (p=0.021).

July 1, 2015Open Access

Effects of cigarette smoking on morphological features of platelets in healthy men

FGFarahnaz GhahremanfardSemnan University of Medical Sciences VSVahid SemnaniKowsar Hospital RGRaheb GhorbaniSemnan University of Medical Sciences

Key Result

Cigarette smoking in healthy men was associated with a significantly higher mean platelet count (264.1 vs 247.7/µl) and lower plateletcrit values (18.0% vs 25.0%) compared to non-smokers.

Study Design

Type

Cross-Sectional (n=542)

Multicenter

Structured PICO

Does cigarette smoking alter platelet morphological parameters in healthy men?

Population

542 healthy men aged 20 to 88 years, free of hematological or cardiopulmonary disorders, evaluated cross-sectionally to compare platelet indices between smokers and non-smokers.

Exposure

Cigarette smoking (≥10 cigarettes per day for >12 months)

Comparator

Non-smokers

Outcome

Platelet indices including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT)surrogate

Cigarette smoking in healthy men is associated with increased platelet count and decreased plateletcrit, indicating morphological changes that may relate to thrombotic risk.

Main Result

Absolute Event Rate: 264.1% vs 247.7%

p-value: p=0.021

Limitations

Relatively small sample size
Lack of investigation of women due to their denial of smoking

Abstract

OBJECTIVES: To assess the effects of cigarette smoking on thrombocytopoiesis and some platelet morphological parameters in healthy male smokers. METHODS: In this cross-sectional study, 542 consecutive healthy men (aged 20 to 88 years), referred to the laboratory of Fatemieh Hospital, Semnan, Iran, between November 2011 and November 2012 for checking up were enrolled. The subjects were divided into 2 groups of smokers (n=258 with frequency of 10 or more cigarette per day with more than 12 months duration of smoking) and non-smokers (n=284). The blood samples were extracted to examine values of platelet indices using an ABX Micros 60 cell counter. RESULTS: Comparing platelet indices across smokers and non-smokers showed that the mean platelet count was statistically significantly higher in adult smokers than in nonsmokers (264.1 ± 81.2/µl versus 247.7 ± 83.9/µl, p=0.021), while the mean plateletcrit value was contrarily lower in the adult smokers (18.0 ± 12.0% versus 25.0 ± 10.0%, p less than 0.001). Other platelet indicators were not discrepant between the smokers and non-smokers. CONCLUSION: Cigarette smoking in healthy individuals results in significant and considerable effects on platelet morphological indices. The mean platelet count is significantly increased, and plateletcrit values are reduced, compared with non-smoking status.

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