September 1, 1979
View Full PaperInhibition of Spontaneous Transformation of Rat Embryo Cells Releasing Endogenous Type C Virus by Virus-Specific Antiserum23
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Abstract
Noninbred Sprague-Dawley rat embryo cell clones predictably undergo transformation after 20-30 in vitro passages following spontaneous release of endogenous rat leukemia virus (RaLV). In the presence of RaLV-specific antiserum, virus production and infectivity were reduced and transformation was delayed from 6 to 25 weeks. Transformation was not associated with an increased expression of Kirsten murine sarcoma virus-related src gene RNA.