Does ticagrelor protect against reperfusion injury and improve heart function compared to clopidogrel after myocardial infarction?
Myocardial infarction model undergoing reperfusion
Ticagrelor (administered acutely just before reperfusion, chronically for 4 weeks, or a combination of both)
Clopidogrel (achieving a similar degree of platelet inhibition)
Reperfusion injury and heart function/remodelingsurrogate
Ticagrelor offers cardioprotective benefits against reperfusion injury and improves post-MI remodeling independent of its antiplatelet effects, unlike clopidogrel.
Ticagrelor, but not clopidogrel, administered just before reperfusion protects against reperfusion injury. This acute treatment or chronic ticagrelor for 4 weeks or their combination improved heart function, whereas clopidogrel, despite achieving a similar degree of platelet inhibition, had no effect.
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Yumei Ye
Gilad D. Birnbaum
J. R. Perez‐Polo
Arteriosclerosis Thrombosis and Vascular Biology
Baylor College of Medicine
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Ye et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69d570aa75589c71d767de18 — DOI: https://doi.org/10.1161/atvbaha.115.305655