Does a multifaceted anticoagulation strategy improve the time anticoagulation parameters are within range in children supported on ECMO?
A multifaceted anticoagulation monitoring strategy in pediatric ECMO slightly improves time in therapeutic range but alters the correlation between HID and aPTT, highlighting the need for further study.
A multipronged monitoring regimen slightly increased the amount of time that anticoagulation parameters were within range. Correlations between the HID and the aPTT differed based on anticoagulation protocol, with a positive correlation in the older protocol and no correlation in the new protocol. This may highlight a problem in study design and analysis that requires further examination. Further trials are needed to assess the most useful markers with which anticoagulation protocols for ECMO can be created, adjusted, and evaluated.
Kessel et al. (Sat,) studied this question.