Frequent right ventricular outflow tract premature ventricular complexes (≥10,000/24 hours) were associated with a 34% prevalence of LV dysfunction compared to 4% with <1000/24 hours (P=0.02).
Observational (n=108)
Is a higher burden of RVOT PVCs associated with an increased prevalence of LV dysfunction in patients without structural heart disease?
Frequent RVOT PVCs, particularly a burden of >=10,000/24 hours, and non-sustained VT are significantly associated with LV dysfunction in patients without underlying structural heart disease.
Effect estimate: OR 3.6 (95% CI 1.3-10.1)
Absolute Event Rate: 34% vs 4%
p-value: p=0.02
BACKGROUND: Recent case series have shown reversal of left ventricular (LV) dysfunction after catheter ablation of frequent premature ventricular complexes (PVCs) originating from the right ventricular outflow tract (RVOT). We conducted a retrospective study to evaluate the prevalence of patients with frequent RVOT PVCs (> or =10 per hour) and LV dysfunction. METHODS: RVOT PVC was defined as PVC with left bundle branch block morphology and inferior axis on a 12-lead ECG. We included patients with frequent RVOT PVCs on 24-hours Holter monitor who had a recent evaluation of LV function. Patients with structural heart disease, including obstructive coronary artery disease, were excluded. Patients were divided into three groups based on the number of PVCs ( or =10,000/24 hour), and the prevalence of LV dysfunction was evaluated in each group. RESULTS: Our analysis included 108 patients: 24 patients had or =10,000PVCs/24 hour. The prevalence of LV dysfunction was 4%, 12%, and 34%, respectively (P = 0.02). With logistic regression analysis, non-sustained ventricular tachycardia was an independent predictor of LV dysfunction with odds ratio of 3.6 (1.3-10.1). CONCLUSION: We demonstrated a significant association between frequent RVOT PVCs and LV dysfunction in patients without structural heart disease.
Kanei et al. (Tue,) conducted a observational in Frequent premature ventricular complexes originating from the right ventricular outflow tract (n=108). Frequent RVOT PVCs (≥10,000/24 hour) vs. <1000 PVCs/24 hour was evaluated on Prevalence of left ventricular dysfunction (OR 3.6, 95% CI 1.3-10.1, p=0.02). Frequent right ventricular outflow tract premature ventricular complexes (≥10,000/24 hours) were associated with a 34% prevalence of LV dysfunction compared to 4% with <1000/24 hours (P=0.02).