MitraClip implantation demonstrated a 25.9% overall in-hospital complication rate and a 12.8% major complication rate, with low rates of in-hospital death (2.2%) and stroke (0.9%).
Observational (n=828)
Yes
What are the rates of in-hospital complications and MACCE following MitraClip implantation in a real-world registry?
MitraClip implantation in a real-world registry demonstrated a safe profile with low rates of MACCE and clip-specific complications, though major bleeding remains a notable risk.
AIMS: To analyze risk and outcomes of complications during and after MitraClip implantation using multicenter data from the prospective German Transcatheter Mitral Valve Interventions (TRAMI) registry. METHODS AND RESULTS: Data of 828 patients (mean age: 76.0 71-81 years, 327 (40%) females) undergoing MitraClip implantation in Germany between 2010 and 2013 were analyzed. Most patients (85%) underwent elective procedures with on average implantation of 1.4 ± 0.6 clips. Emergent cardiac surgery was not required; a single patient died intraoperatively. During the in-hospital period, complications occurred in 215 (25.9%) patients, of which 106 (12.8%) were considered major. Major bleeding complications were among the most frequent major complications (7.4%), while rates of pericardial tamponade (1.9%) and clip-specific complications (embolization: 0%, partial clip detachment: 1.9%) were low. In-hospital death, stroke or myocardial infarction (MACCE) occurred in 2.2, 0.9, and 0% patients, respectively. Patients with complications appeared to be older and more critically ill pre-interventionally; in-hospital mortality was significantly higher as compared to those without procedural complications. CONCLUSIONS: MitraClip implantation appears to be a safe treatment option with low rates of MACCE and clip-specific complications. Nevertheless, MitraClip therapy is not without complications. Careful patient selection and improvements in preventing peri-procedural bleeding have the potential of reducing post-procedural complications and improving outcomes.
Eggebrecht et al. (Mon,) conducted a observational in Mitral regurgitation requiring MitraClip (n=828). MitraClip implantation was evaluated on In-hospital complications. MitraClip implantation demonstrated a 25.9% overall in-hospital complication rate and a 12.8% major complication rate, with low rates of in-hospital death (2.2%) and stroke (0.9%).
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