Small dense low-density lipoprotein cholesterol (sdLDL-C) was significantly associated with carotid artery intima-media thickness (β = 0.437, p < 0.001) independent of traditional cardiovascular risk factors in a healthy Chinese population.
Cross-Sectional (n=183)
No
Does small dense low-density lipoprotein cholesterol (sdLDL-C) correlate with carotid artery intima-media thickness (CA-IMT) in a healthy Chinese population?
Small dense LDL-C is independently associated with carotid artery intima-media thickness in a healthy Chinese population, suggesting its utility as a predictor of early atherosclerosis.
Effect estimate: β = 0.437
p-value: p=<0.001
BACKGROUND: Small dense low-density lipoprotein cholesterol (sdLDL-C) concentration was useful in the assessment of the presence of cardiovascular diseases (CVD) and its severity. We examined whether SdLDL-C is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and traditional CVD risk factors in Chinese healthy subjects. METHODS: We measured CA-IMT, blood pressure (BP), sdLDL-C, glucose metabolism and lipid in 183 native Chinese healthy subjects. CA-IMT was assessed by ultrasonography, and sdLDL-C concentrations were measured by a homogenous assay. Pearson's correlation coefficient analyses and Multiple regression analyses were used to examine the relationships between CA-IMT values and other clinical variables. RESULTS: The sdLDL-C level was significantly higher in males than in females (p <0.05) and there was an age effect on sdLDL-C (p <0.05). When the effects of age, gender and other traditional CVD risk factors were adjusted using multiple regression analysis. CA-IMT remained significantly associated with sdLDL-C(β = 0.437, p <0.001). CONCLUSIONS: There are gender and age differences in sdLDL-C levels among a healthy Chinese population. Moreover, we found adjusted traditional CVD risk factors such as higher age, male sex, and other traditional CVD risk factors, the association between CA-IMT and SdLDL-C remained significant. sdLDL-C is may be a useful predictor in the assessment of CA-IMT in Chinese population.
Shen et al. (Wed,) conducted a cross-sectional in Healthy (n=183). Small dense low-density lipoprotein cholesterol (sdLDL-C) vs. Standard lipid parameters and traditional CVD risk factors was evaluated on Association between carotid artery intima-media thickness (CA-IMT) and sdLDL-C (multivariate adjusted) (β = 0.437, p=<0.001). Small dense low-density lipoprotein cholesterol (sdLDL-C) was significantly associated with carotid artery intima-media thickness (β = 0.437, p < 0.001) independent of traditional cardiovascular risk factors in a healthy Chinese population.
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