Key points are not available for this paper at this time.
The first industrial applications of chiral ferrocenyl lignds of the Josiphos type have recently been disclosed. Compound 1a is used in the Rh-catalyzed, asymmetric hydrogenation of 2, a precursor in a new commercial synthesis of (+)-biotin. Ligand 1b is part of the highly active Ir catalyst used for the reduction of imine 3, from which the herbicide (S)-Metolachlor is made.
Antonio Togni (1996) studied this question.