Nifedipine microgranules and nifedipine osmotic pump achieved similar rates of goal blood pressure control at 8 weeks (71% vs 78%, P=0.12).
RCT (n=192)
Double-blind
Double-dummy
Yes
Does nifedipine microgranules compared to nifedipine osmotic pump improve blood pressure control in patients with mild to moderate essential hypertension?
Both nifedipine microgranules and nifedipine osmotic pump formulations are equally effective and well-tolerated for achieving target blood pressure in patients with mild to moderate essential hypertension.
Absolute Event Rate: 71% vs 78%
p-value: p=0.12
INTRODUCTION: Controlled clinical studies have clearly established the advantages of blood pressure (BP) reduction. However, optimal control of BP in the population is still not adequate. Monotherapy is ineffective in the majority of hypertensive patients, and multidrug therapy increases costs. OBJECTIVE: The objective of the study was to assess to what extent and how uniformly BP can be controlled with two different 24-hour drug-releasing formulations of nifedipine, used as monotherapy. METHODS: One hundred ninety-two patients of both genders, aged 18 to 65 years, with mild to moderate (Stage 1 and 2) essential hypertension with systolic BP 1.4 and T/P ratios of >0.5 was similar in both groups. An important correlation was found between the SI and T/P values. The incidence of adverse effects was low and similar in both groups. CONCLUSIONS: Target BP was reached in more than 70% of patients receiving monotherapy with either formulation. Both formulations were tolerated well.
Roa et al. (Thu,) conducted a rct in Essential hypertension (n=192). Nifedipine microgranules vs. Nifedipine osmotic pump was evaluated on Goal BP (<140/<90 mm Hg) (p=0.12). Nifedipine microgranules and nifedipine osmotic pump achieved similar rates of goal blood pressure control at 8 weeks (71% vs 78%, P=0.12).