Myosin-V is a versatile motor involved in short-range vesicle transport that forms a complex with kinesin to regulate the transition of vesicles from microtubules to actin filaments.
Describes the molecular mechanisms by which Myosin-V coordinates with Rab proteins and kinesin to regulate short-range and long-range vesicle transport.
Myosin-V is a versatile motor involved in short-range transport of vesicles in the actin-rich cortex of the cell. It binds to several different kinds of vesicles, and the mechanism by which it interacts with the vesicle surface is being unraveled, primarily in melanocytes. Members of the Rab family of G-proteins are required for the recruitment of myosin-V to vesicles. Rab27a and its rabphilin-like effector protein, Melanophilin, recruit myosin-Va to melanosomes and appear to serve as the membrane receptor. Myosin-V is also involved in fast axonal/dendritic transport and, interestingly, it forms a complex with kinesin, a microtubule-based motor. This kinesin/myosin-V heteromotor complex allows long-range movement of vesicles within axons and dendrites on microtubules and short-range movement in the dendritic spines and axon terminals on actin filaments. The direct interaction of motors from both filament systems may represent the mechanism by which the transition of vesicles from microtubules to actin filaments is regulated.
George M. Langford (Sun,) reported a review. Myosin-V was evaluated. Myosin-V is a versatile motor involved in short-range vesicle transport that forms a complex with kinesin to regulate the transition of vesicles from microtubules to actin filaments.
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