Myocardial T1 and ECV measurement using 3T cardiac MRI showed excellent reproducibility but no significant difference between asymptomatic moderate-severe AS patients and controls (P > 0.05).
Observational (n=72)
Is 3T cardiac MRI measurement of myocardial T1 and ECV reproducible, and does it differ between asymptomatic patients with moderate-severe aortic stenosis and age-matched controls?
Myocardial T1 and ECV quantification using MOLLI on 3T MRI is highly reproducible in aortic stenosis but shows no significant difference between asymptomatic moderate-severe AS patients and age-matched controls.
Absolute Event Rate: 1103.32% vs 1092.27%
p-value: p=> 0.05
AIMS: (i) To establish the test-retest reproducibility of myocardial T1 and extracellular volume (ECV) fraction measurement in asymptomatic patients with moderate-severe aortic stenosis (AS), (ii) to compare reproducibility using motion-corrected (MOCO) parametric T1 maps for analysis vs. full MOLLI series of images, and (iii) to compare T1 and ECV between patients and age-matched controls. METHODS AND RESULTS: 3 T cardiac MRI was performed twice on 10 patients (median interval 7 days) to assess reproducibility. An additional 40 patients and 22 asymptomatic controls underwent a single MRI. Native T1 and ECV were calculated by outlining the myocardium on T1 maps generated inline, and using an offline T1 fit on the MOCO multiple inversion-time raw image series, in the reproducibility cohort (n = 10). Reproducibility was excellent using the inline T1 maps (CoVs for T1: 1.77%; ECV: 6.52%) and good using the full MOLLI series (CoVs for T1: 8.52%; ECV: 12.98%). On comparing AS and controls, who were well matched for age, gender and co-morbidities, there was no significant difference in the native T1 or ECV (T1 = 1103.32 ± 33.07 vs. 1092.27 ± 34.29; ECV = 0.243 ± 0.019 vs. 0.251 ± 0.026 in patients and controls, P > 0.05), which was maintained even after splitting the patients into moderate and severe AS subgroups. CONCLUSION: The test-retest reproducibility of myocardial T1 quantification using MOLLI is excellent in patients with AS and is highest using inline generated T1 maps for analysis. There was no difference in native myocardial T1 or ECV between asymptomatic patients with moderate-severe AS and age-matched controls without valve disease.
Singh et al. (Fri,) conducted a observational in Moderate-severe aortic stenosis (n=72). 3 T cardiac MRI for myocardial T1 and ECV measurement vs. Age-matched controls was evaluated on Native T1 (p=> 0.05). Myocardial T1 and ECV measurement using 3T cardiac MRI showed excellent reproducibility but no significant difference between asymptomatic moderate-severe AS patients and controls (P > 0.05).