Correlations between serum cholesterol and systolic blood pressure with national coronary heart disease mortality increased over time, reaching r=+0.96 and r=+0.64 respectively by 1974-1976.
Observational
Yes
Does exposure to major coronary risk factors correlate with coronary heart disease mortality over time in men aged 40-59?
The study demonstrates that the maximum effects of major coronary risk factors like cholesterol and blood pressure on mortality may take 10 years or more to manifest, highlighting the long 'incubation period' of coronary heart disease.
Effect estimate: r = +0.96 for serum cholesterol and r = +0.64 for systolic blood pressure (at 1974-6)
Serum cholesterol concentrations and blood pressure were measured during 1958–64 among men aged 40–59 who took part in the Seven Countries Study. In the present study these measurements were related to the national mortality from coronary heart disease in the periods 1959–61, 1964–6, 1969–71, and 1974–6. The correlations increased with time (r = +0.86, 0.90, 0.93, and 0.96 respectively for serum cholesterol concentration and r = +0.48, 0.56, 0.57, and 0.64 for systolic blood pressure), suggesting that the ‘incubation period’ between exposure to major coronary risk factors and the maximum effects on mortality may be 10 years or more.
Geoffrey Rose (Fri,) conducted a observational in Coronary heart disease. Serum cholesterol concentration and systolic blood pressure was evaluated on National mortality from coronary heart disease (r = +0.96 for serum cholesterol and r = +0.64 for systolic blood pressure (at 1974-6)). Correlations between serum cholesterol and systolic blood pressure with national coronary heart disease mortality increased over time, reaching r=+0.96 and r=+0.64 respectively by 1974-1976.