Newly diagnosed coronary artery disease was associated with significantly higher aortic stiffness (Ep 212 vs 123 kN/m2; P<0.01) and left ventricular mass index compared to matched healthy controls.
Case-Control (n=110)
Is previously unknown coronary artery disease associated with increased aortic stiffness and altered left ventricular structure compared to matched controls?
Newly diagnosed coronary artery disease is associated with increased aortic stiffness and left ventricular mass, which may help explain the link between elevated pulse pressure and cardiovascular mortality.
Absolute Event Rate: 212% vs 123%
p-value: p=<0.01
To elucidate the relationship between coronary artery disease (CAD), aortic stiffness, and left ventricular structure, we recruited 55 subjects (33 men; average age, 63+/-1 years) with previously unknown CAD from a healthy general population sample, as well as 55 control subjects matched for gender, age, and serum cholesterol level. We measured arterial blood pressure and the systolic expansion of the transverse aorta and left ventricular structure by echocardiography. Aortic stiffness was higher in CAD patients than in controls, with a brachial pulse pressure of 59+/-3 versus 52+/-2 mm Hg and stiffness indices of Ep=212+/-26 versus 123+/-13 kN/m2 and beat=16+/-2 versus 9+/-1 (all P<0.01). Mean arterial pressure was similar in both groups during the measurements (95+/-2 versus 93+/-2 mm Hg, P=NS). Most CAD patients (61%) were in the highest stiffness quartile defined by the normal control values (P<0.05 versus control). Left ventricular mass index was also higher in CAD patients than in matched controls (139+/-5 versus 123+/-4 g/m2, P<0.05). We conclude that aortic stiffness and left ventricular mass are increased in subjects newly diagnosed as having CAD. This might explain previously reported associations of an increased mortality, particularly from CAD, found among subjects with elevated pulse pressures.
Gatzka et al. (Tue,) conducted a case-control in Coronary artery disease (n=110). Coronary artery disease vs. Matched healthy controls was evaluated on Aortic stiffness index (Ep) (p=<0.01). Newly diagnosed coronary artery disease was associated with significantly higher aortic stiffness (Ep 212 vs 123 kN/m2; P<0.01) and left ventricular mass index compared to matched healthy controls.