In a Tibetan population living at 3660 meters, an increase in waist-to-hip ratio by 0.1 unit was associated with a 0.25 mmol/L increase in triglycerides.
Cross-Sectional (n=371)
No
In a high-altitude Tibetan population, there is a high prevalence of dyslipidemia, with waist-to-hip ratio significantly correlating with adverse lipid profiles.
Effect estimate: Coefficient 2.55 mmol/L (95% CI 1.65-3.44)
p-value: p=<0.05
The aim of this study was to determine the prevalence of abnormal lipid levels and its association with selected coronary heart disease (CHD) risk factors in the Tibetan population living at 3660 meters above sea level in Lhasa, Tibet. Three hundred seventy one randomly selected male and female, aged 30 to 70 yr took part in the study. Based on the National Cholesterol Education Programme (NCED) adult treatment panel ATP-III 2004 criteria, the age-adjusted prevalence of hypertriglyceridemia was 12.0%; high triglycerides (TG), 33.4%; high low-density lipoprotein cholesterol (LDL-C), 4.8%; and low high-density lipoprotein cholesterol (HDL-C); 24.3%. After adjusting for age, sex, smoking, alcohol, physical activity, diet, hemoglobin (Hb) concentration, and systolic and diastolic blood pressure (BP), an increase in waist-to-hip ratio (WHR) by 0.1 unit was associated with a statistically significant increase in TG, total cholesterol (TC) and LDL-C by 0.25 mmol/L, 0.24 mmol/L, and 0.18 mmol/L, respectively. Female gender increased HDL-C by 0.18 mmol/L when compared with males. Age-adjusted prevalences of Framingham CHD risk score for males and females were 16.3% and 0.6%, respectively. This study demonstrated a high prevalence of hypertriglyceridemia in males, a higher prevalence of low HDL-C in females, and a high hypercholesterolemia prevalence in both genders. However, further longitudinal studies assessing CHD risk factors in high altitude natives are required.
Sherpa et al. (Thu,) conducted a cross-sectional in Dyslipidemia (n=371). Waist-to-hip ratio (WHR) was evaluated on Change in triglycerides (TG) per 1 unit increase in waist-to-hip ratio (WHR) (Coefficient 2.55 mmol/L, 95% CI 1.65-3.44, p=<0.05). In a Tibetan population living at 3660 meters, an increase in waist-to-hip ratio by 0.1 unit was associated with a 0.25 mmol/L increase in triglycerides.