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Abstract. Using two separate electrophoretic techniques the presence of pre‐β‐1 lipoprotein fraction in serum has been studied in a series of 46 patients. Twenty‐five of these had normal coronary arteries and 21 coronary atherosclerosis documented by angiography. Six patients with normal coronaries (24%) and 11 with coronary artery disease (52%) had pre‐β‐1 in the serum ( p <0.05). The distribution of elevated serum cholesterol and/or triglycerides was roughly equal in the two angiographically different groups. The occurrence or absence of the pre‐β‐1 lipoprotein fraction was related to the family history for coronary heart disease, yielding suggestive evidence of a genetically determined lipid abnormality.
Frick et al. (Sat,) studied this question.