Increases in depressive symptoms and fibrinogen levels were significantly correlated over 21 months, with fibrinogen changes predicting depression changes when accounting for baseline fibrinogen.
Cohort (n=57)
Do longitudinal changes in depressive symptoms correlate with changes in plasma fibrinogen levels in school teachers?
Longitudinal increases in depressive symptoms correlate with increases in the inflammatory and CAD risk marker fibrinogen, suggesting a dynamic psychobiological relationship.
Depression and anxiety previously predicted coronary artery disease (CAD) risk. Inflammation contributes to CAD and shows an association with depression. We followed 57 teachers (mean 49+/-8 years) over 21 months and investigated whether changes in depressive and anxiety symptoms relate to those in the CAD risk and inflammation marker fibrinogen and vice versa. Increase in depressive symptoms and in fibrinogen levels were significantly correlated. While controlling for baseline depression rendered the association between changes in depression and fibrinogen nonsignificant, taking into account baseline fibrinogen levels maintained the predictive value of fibrinogen change for depression change. Anxiety and fibrinogen changes were not significantly correlated. This dynamic relationship between depression and the inflammatory biomarker fibrinogen might advance our knowledge about psychobiological mechanisms underlying both CAD and sickness behavior.
Känel et al. (Wed,) reported a cohort. Changes in depressive symptoms and fibrinogen levels was evaluated on Correlation between changes in depressive symptoms and fibrinogen levels. Increases in depressive symptoms and fibrinogen levels were significantly correlated over 21 months, with fibrinogen changes predicting depression changes when accounting for baseline fibrinogen.