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With the use of positron emission tomography (PET) and the 15 O steady-state- 18 Ffluorodeoxyglucose combined method, the local interrelationships between the cerebral metabolic rate for oxygen (CMRO 2 ) and the cerebral metabolic rate for glucose (CMRGlc) were investigated in control subjects and in stroke patients. In addition to the classic in vivo autoradiographic approach, a kinetic method was used to measure CMRGlc because it was expected to be more reliable in cerebral ischemia. In control subjects local coupling between CBF, CMRO 2 , and CMRGlc was confirmed, and acceptable values for the CMRO 2 /CMRGlc ratio were found; the latter, however, was lower in white matter than in gray. Uncoupling between CMRO 2 and CMRGlc was observed in all stroke patients, suggesting that (1) enhanced anaerobic glycolysis occurred both in reperfused recent infarcts and in chronically ischemic tissue, and (2) substrates other than blood-borne glucose were being oxidized at the borders of recent infarcts. However, methodological uncertainties presently make such observations only tentative. Finally, a coupled depression of CMRO 2 and CMRGlc was found in the contralateral cerebellum.
Baron et al. (Fri,) studied this question.