Ethanol Potentiation of Aspirin-Induced Prolongation of the Bleeding Time

THE template bleeding time is a sensitive and reproducible measure of primary hemostasis. It is influenced by platelet function and vascular tone, as well as by platelet number.1 Usually after a normal subject ingests 325 mg of aspirin the bleeding time is moderately prolonged, reaching its peak of approximately twice base-line values within 12 hours and returning to approximately base-line levels by 24 hours. In two subjects who had taken 325 mg of aspirin we observed a second rise in the bleeding time — at 36 hours after ingestion in one and 60 hours in the other — to levels . . .