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A few years ago I gave a number of patients with hypertension potassium or sodium thiocyanate with results that were generally unsatisfactory. Some showed extreme weakness, nausea and dizziness, while an occasional one seemed to be considerably improved as far as the symptoms and blood pressure level were concerned. In general, it seemed that older patients or those who had a blood pressure elevation over a long period of time seemed to tolerate cyanate therapy less well than the younger group. Careful observation indicated that individual dosage was necessarily dependent on the individual response and the toxicity. An attempt has been made, therefore, to gage the dosage by a study of the cyanate clearance from the body through the urine and a correlation by the blood cyanate level and the blood pressure. The following material is being presented as a preliminary report on such observations extending over a period of
M. HERBERT BARKER (Sat,) studied this question.
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