Stroke before age 55 was significantly associated with hypertension, diabetes, heart disease, and smoking (P<0.05-0.001), as well as oral contraceptive use in women under 40 (P<0.001).
Case-Control (n=1,228)
No
What are the etiological characteristics and risk factors associated with cerebrovascular disease before age 55?
Traditional cardiovascular risk factors, including hypertension, diabetes, and smoking, are significantly associated with both ischemic and hemorrhagic stroke in patients under 55 years of age.
p-value: p=<0.05-0.001
The etiological characteristics of cerebrovascular disease (CVD) before the age of 55 are reviewed in 399 patients admitted to the Department of Neurology, Karolinska Hospital, Stockholm, from 1973-77. The material was well-defined with regard to subtypes of stroke as well as to the diseased population. The control material consists of 829 males and females of corresponding age randomly selected from the Stockholm population. In the ischemic group, 61% had angiographic evidence of atherosclerosis and, compared to controls, in most patient groups a significant (P less than 0.05-0.001) association with hypertension, diabetes, heart disease and smoking was found as well as for female patients under age 40 the use of oral contraceptives (P less than 0.001). In the hemorrhagic group, angiography demonstrated aneurysms in 76% of the patients with subarachnoidal bleeding but also atherosclerotic lesions in about 12% of the whole group. This would imply that atherosclerosis is an important precursor also for hemorrhagic lesions, further supported by a significant (P less than 0.01-0.001) association of hypertension, diabetes and smoking with this group.
Mettinger et al. (Thu,) conducted a case-control in Cerebrovascular disease (stroke) (n=1,228). Risk factors (hypertension, diabetes, heart disease, smoking, oral contraceptives) vs. Population controls was evaluated on Association with risk factors (p=<0.05-0.001). Stroke before age 55 was significantly associated with hypertension, diabetes, heart disease, and smoking (P<0.05-0.001), as well as oral contraceptive use in women under 40 (P<0.001).