What is the clinical evidence from this study?

Study design: Other. Population: Overweight/obesity (n=15). Intervention: Jogging training vs. Walking training. Primary outcome: Pre-heparin serum LPL concentration (p=0.033).

January 1, 2010Open Access

Twelve-Week Jogging Training Increases Pre-Heparin Serum Lipoprotein Lipase Concentrations in Overweight/Obese Middle-Aged Men

Key Result

Twelve weeks of supervised jogging training significantly increased pre-heparin serum LPL concentrations from 37.6 to 51.0 ng/mL in overweight/obese middle-aged men, whereas walking had no significant effect.

Structured PICO

Does 12 weeks of supervised jogging training increase pre-heparin serum LPL concentrations in overweight/obese middle-aged men?

Population

15 overweight/obese middle-aged men, free of medications affecting lipid metabolism, followed for 12 weeks of supervised exercise.

Intervention

12 weeks of supervised jogging training (gradually increasing to 60 min/day, 3 days a week at 75-80% of age-predicted maximal heart rate).

Comparator

12 weeks of supervised brisk walking training (gradually increasing to 60 min/day, 3 days a week at 65-70% of age-predicted maximal heart rate).

Outcome

Pre-heparin serum lipoprotein lipase (LPL) concentrations at 12 weeks.surrogate

Main Result

Absolute Event Rate: 51% vs 42.9%

p-value: p=0.033

Limitations

Small sample size
Pre-heparin serum LPL only represents a small fraction of total LPL and is catalytically inactive
Cannot distinguish between adipose tissue-derived LPL and skeletal muscle-derived LPL
Uncertain if the increased pre-heparin serum LPL concentrations are from the chronic effects of training or the acute effects of exercise

Abstract

AIM: Enhancement of lipoprotein lipase (LPL) activity through drug administration has been shown to increase pre-heparin serum LPL concentrations; however, pre-heparin serum LPL responses to exercise training have not been determined. The present study was undertaken to investigate the effects of 12 weeks of supervised aerobic exercise training on pre-heparin serum LPL concentrations in overweight/obese men. METHODS: Fifteen overweight/obese middle-aged men were assigned to one of two 12-week supervised exercise interventions: a walking group (eight participants gradually increasing brisk walking to 60 min/day 3 days a week) or a jogging group (seven participants gradually increasing jogging to 60 min/day 3 days a week). All participants maintained ad libitum diets. Blood samples were collected at baseline and immediately after 12 weeks. The primary outcome was pre-heparin serum LPL. RESULTS: Pre-heparin serum LPL concentrations were increased in the jogging group after 12 weeks compared with the baseline values (mean+/-SEM: 37.6+/-4.7 vs. 51.0+/-6.6 ng/mL, respectively, p= 0.033). In the walking group, pre-heparin serum LPL concentrations remained unchanged after 12 weeks. CONCLUSIONS: This study demonstrates that 12 weeks of jogging training increases pre-heparin serum LPL concentrations in overweight/obese middle-aged men.

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