Older age was associated with decreased time-averaged aortic wall shear stress, whereas the oscillatory shear index remained unaffected by aging.
Observational (n=18)
Does aging affect aortic wall shear stress magnitude and oscillatory shear index?
Aortic wall shear stress magnitude decreases with age, likely due to increased aortic diameter and decreased stroke volume, which may have implications for vascular disease initiation.
This study found a significant correlation between wall shear stress magnitude and age. Wall shear stress magnitude in the aorta decreases by increasing age. Oscillatory shear index in the aorta remains unaffected by aging. Change in WSS might have implications for disease initiation and progression. The size of the larger arteries increases during the entire life, but not much is known about how the change in size affects the blood flow. This study compares the flow field in a group of young males ( N = 10, age = 23.5 ± 1.4), with a group of older males ( N = 8, age = 58.0 ± 2.8). Aortic geometries were obtained by magnetic resonance imaging, and the aortic blood flow field was computed using computational fluid dynamics. The aortic wall shear stress was obtained from the computations, and it was concluded that time-averaged wall shear stress decreased with increased age, probably as a consequence of increased aortic diameter and decreased stroke volume, which in turn reduces the shear rates in the aorta. However, the oscillatory shear index, which is a measure of the oscillatory nature of the wall shear stress vector, seemed to be unaffected by aging.
Lantz et al. (2015) reported an observational. Older age vs. Young age was evaluated on Time-averaged wall shear stress and oscillatory shear index. Older age was associated with decreased time-averaged aortic wall shear stress, whereas the oscillatory shear index remained unaffected by aging.